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jia tu you suan xing ji xing hu xi jiong po zong he zheng shi fei dong mai xue ya de bian hua
Pages: 293-299
Year: Issue:  3
Journal: Acta Physiologica Sinica

Keyword:  acute respiratory distress syndromeoleic acidpulmonary arterial pressurepulmonary vascular resistancehexamethoniumphentolamine;
Abstract: This paper reports the changes in pulmonary arterial pressure during theacute respiratory distress syndrome caused by oleic acid injection in rabbits. Follow-ing intravenous injection of oleic acid the pulmonary vascular resistance was foundto be increased markedly while the arterial pressure, heart rate and the cardiacoutput were lowered. The pulmonary arterial pressure was increased accordinglywhich showed phasic alterations, i.e., initial rapid rise, relative stable period anda subsequent late increase. Pretreatment with ganglionic blocking agent-hexame-thonium as well as αblocker-phentolamine abolished the initial rapid rise of pulmo-nary arterial pressure following injection of oleic acid. Bilateral severance ofsinus nerves or cervical vagus nerves had no effect. Moreover, neither hexam-ethonium nor phentolamine could block the rise of pulmonary arterial pressurein the late stage. It is thus assumed that the initial rapid rise of pulmonary arterial pressure fol-lowing injection of oleic acid involves the activities of sympathetic nerves, whileits late increase is mainly due to the ensuing anoxia and the relevant factors involved.
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