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Determination of serum digoxin by chemiluminescent enzyme immunoassay
Author(s): 
Pages: 143-145
Year: Issue:  3
Journal: JIANGXI JOURNAL OF MEDICAL LABORATORY SCIENCES

Keyword:  化学发光酶免疫分析血清地高辛浓度药物监测碱性磷酸酶;
Abstract: 目的评价化学发光酶免疫法测定地高辛血药浓度.了解临床地高辛的应用状况.方法采用该法测定地高辛标准品及临床慢性心功能不全、正接受地高辛治疗者血药浓度与14个生化指标比较分析.结果该法批内、批间精密度分别为2.58%和5.13%,浓度处在治疗范围者仅26/71,偏低组36/71,偏高组9/71.BUN、CK、AKP在血药浓度低、中、高三组间P<0.01,LDH、Cr、K+、Na+组间P<0.05.BUN、AKP、K+正常组与增高组间血药浓度P<0.05,SDCs偏高组中AKP、LDH、CK含量与对照组比较均P<0.01,且SDCs与AKP的相关系数r=0.6737.结论化学发光酶免疫法是一种快速、可靠、准确、有效的血药监测法,可作为判断药物疗效的客观指标,肾功能减退及电解质失衡可影响血药浓度.地高辛使用可影响到骨骼肌,其中以AKP升高较为明显.
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