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feng shi xing xin zang bing huan zhe xin ji xin yuan xing a pian zuo han liang de bian hua ji qi dui xin gong neng de ying xiang
Author(s): 
Pages: 34-38
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  内源性阿片肽风湿性心脏病心功能;
Abstract: 目的:探讨心肌内源性阿片肽(EOP)的变化和对术前心功能的影响及其可能的机制。方法:应用放射免疫法测定21例风湿性二尖瓣病变患者心肌中β-内啡肽(β-EP)、亮脑啡肽(Leu-ENK)和强啡肽A1-13(DynA1-13)以及cAMP和cGMP含量。结果:风心病二尖瓣狭窄组(MS组)、二尖瓣关闭不全组(MI组)心肌β-EP、Leu-ENK和DynA1-13含量均显著高于正常对照组(P<0.01);MI组心肌β-EP、Leu-ENK含量显著高于MS组(P<0.05),DynA1-13含量在MI和MS两组间无统计学差异(P>0.05);风心病MS和MI组心肌cAMP含量及cAMP/cGMP比值均显著低于正常对照组(P<0.05),而cGMP含量高于正常对照组(P<0.05);MS和MI两组间cAMP、cGMP含量及cAMP/cGMP比值均无显著差异(P>0.05));心肌β-EP和Leu-ENK含量与LVEF、FS、LCWI、LVSWI、CI、SI呈明显负相关(P<0.05);心肌DynA1-13与LCWI、LVSWI、CI、SI亦呈明显负相关(P<0.05);心肌β-EP、Leu-ENK和DynA1-13含量?
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