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cu yi ye su ba zuo dan nang shou suo su he mi zou shen jing ci ji dui gou yi ye he xue qing zhong yi duo zuo han liang de ying xiang
Pages: 403-409
Year: Issue:  5
Journal: Acta Physiologica Sinica

Keyword:  pancreatic polypeptidesecretincholecystokinin octapeptidevagal stimulation;
Abstract: In acute experiments on anaesthetized dogs,pancreatic polypeptide(PP)con-centrations in pancreatic juice collected from a cannula and in serum were measuredby radioimmunoassay after intravenous injection of secretin(8μg/kg)or cholecy-stokinin octapeptide(CCK_8,40 ng/kg).Similar measurement was made before andafter electrical stimulation of thoracic vagus.It was found that a significant amount of PP-like immunoreactivity waspresent in the basal pancreatic juice with a mean output of 3130±2200 pg/15min which was approximately 40-fold higher than that in serum.There was,however,a marked individual variations.After injection of secretin or CCK_8or after electrical vagal stimulation,the levels of PP in serum and PP output of pan-creatic juice were significantly increased(P0.01),particularly after electricalvagal stimulation.The peak levels of PP output in response to the three waysof stimulation mentioned above usually appeared at the first 15-min period.Themean increased values of PP released into the pancreatic juice by secretin,CCK_8,and vagal stimulation were respectively 105%,52%,and 200%.Exogenoussecretin induced increase of PP goes parallel with that of bicarbonate output in thepancreatic juice,and so is the increase of PP and amylase output in response to CCK_8stimulation.We conclude that pancreatic polypeptide is not only an endocrinebut also an exocrine,the release of which may involve the action of secretin andcholecystokinin and vagal activity.
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