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bu tong wen du han xue xin ji bao hu ye de lin chuang ying yong yan jiu
Pages: 66-68
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  cardioplegiacardiopulmonary bypass;
Abstract: Objective: Twenty patients undergoing cardiac valve replacement were selected for comparing the effect of myocardial protection of blood cardioplegia with different temperature used in cardiopulmonary bypass (CPB). Methods: The patients were divided into deep hypothermic group (the temperature of perfusion sulfate was 15℃~20℃) and moderate hypothermic group(the temperature of perfusion sulfate was 25℃~29℃). Serum creatine kinase(CK) was measured, arteriousvenous blood gas was analysed and oxygen uptaking was calculated. The changes of hemodynamic parameters were recorded and myocardial biopsy was taken. Results: Mild hypothermic group kept better level in HR and CVP after CPB had been stopped. Deep hypothermic group: CK was apparently higher (620±28 UI/L) after the coronary artery was reperfused for 2 h, reached to peak(930±40) UI/L at 4 h and remained at high level (740±47 UI/L) at 24 h; Mild hypothermic group: The change of CK was similar to the deep hypothermic group, but after reperfusion for 24 h its level was lower than that in deep hypothermic group (P0.05), Pathological examination showed the mitochondria and myofilament were destroyed more severely in deep hypothermia group than that in moderate hypothermia group. The heart automation revival rate in moderate hypothermia group was higher than that in deep hypothermia group (66.3% vs 48.7%,P0.05). Conclusion: Perfusion with moderate hypothermia cardioplegia is a better method for the protection of myocardium.
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