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zai gei li xue ping hou de hui fu zhong xiao shu zuo xia xian de qu jia shen shang xian su han liang yu shen jing sheng chang yin zi shui ping de guan xi
Pages: 601-606
Year: Issue:  6
Journal: Acta Physiologica Sinica

Keyword:  mousesubmandibular glandreserpinenoradrenalinenerve growth factorsex differernce;
Abstract: A single dose of reserpine(2mg/kg body weight)depleted the noradrenaline-(NA)content in submandibnlar gland(SMG)of adult IGR/JCL mice of both sexesto unmeasurable levels in 24 hours.Then,the NA content began to recover andreached to pretreatment levels in 12 days.During this period,NA content of themale was always about twice that of the f(?)male.When the preganglionic nervetrunk was avulsed on one side,the NA content of the gland in both sexes fell to about80% of their unoperated sides,but NA content of the male always kept about twicethat of the female during the course of recovery after reserpine.Nerve growth factor(NGF)content in male and female SMG in this strain ofmice was measured by a bioassay method.It was found that the NGF content in themale SMG was about 94-fold higher than that in the female.As exogenous NGFselectively increases tyrosine hydroxylase activity in sympathetic neurons and NAcontent in SMG,the higher NA content of the male SMG than in the female in therecovery course after reserpine might result from endogenous NGF effect on the en-zyme in sympathetic neurons.
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