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tu yan sui fu ce mian hua xue min gan qu dui tong qi de zuo yong
Pages: 450-456
Year: Issue:  5
Journal: Acta Physiologica Sinica

Keyword:  rabbitcentral chemosensitive areaventilationCO_2 response;
Abstract: Experiments were performed on 28 rabbits anaesthetized with chloralose-ure-thane.Filter paper of 1.5mm~2 moistened with mock cerebrospinal fluid of pH7.0,7.34 or 8.0 was placed on different parts of the ventral medullary surface andthe resultant respiratory effects were observed.Topical application of acid an area at the level between the pyramid and the roots of the seventh to tenthcranial nerves(the R area),or to an area medial to the root of the hypoglossal nerve(the C area),led to an increase in V_t,while application of alkaline thesechemosensitive areas diminished V_t.The intermediate areas(theⅠarea)betweenthe R and C areas have no chemosensitivity.In the intact animals,after bilateralapplication of 2% procaine to both R and C areas hyperventilation response tohypercapnia could still be elicited,while application of procaine to Ⅰ areas,onlyhypoventilation response was resulted.In bilateral sinus denervated animals,af-ter applying procaine to R and C areas,hypercapnia could elicite hypoventilationonly,furthermore application of procaine toⅠareas led to apnea.These resultsdemonstrated that in the rabbit there are chemosensitive areas at the ventral sur-face of the medulla.The R and C areas,as well asⅠareas play important rolesin mediating the ventilatory response to hypercapnia.
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