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zuo xing wai xing xiu ke de shen jian zhi ning da mo yi zuo dan zuo han liang de zhu hua
Pages: 256-265
Year: Issue:  3
Journal: Acta Physiologica Sinica

Keyword:  休克止血带有害性大鼠平均含量局部血流毫米汞柱骨折麻醉敲打;
Abstract: The functional changes of the brain of rat during traumatic shock, induced by crushing and beating on the hind limbs, were studied by investigating the changes of the acetylcholine (Ac) content of the brain. The nervous mechanism of traumatic shock was further explored. The Ac content of the brain was markedly increased during traumatic shock, but showed no significant change when shock had been prevented to occur. The increase of the brain Ac content may be taken as an index of central inhibition occurring in the state of shock. Short-period (15-20 min.) application of tourniquet on the root of both hind limbs was shown to be a simple and reliable method for the prevention of shock induced by trauma on the hind limbs. The local circulation as well as the local nervous conduction could be completely blocked by the mechanical compression. On releasing the tourniquet, the local blood flow was restored at once, but the nervous function showed no improvement within the period of observation as long as 30 min. The fact that most of the traumatized animals did not develop shock within this period indicates that the shockprevention effect of the tourniquet depends chiefly on the blockade of the local nervous conduction, the central nervous system being thereby protected against the invasion of the nociceptive impulses coming from the injured area. A direct evidence of the nervous mechanism of shock was afforded by the facts that shock could be induced (1) by traumatizing the perfused hind limb communicating with the rest of the body only by way of nerves, and (2) by the prolonged electrical stimulation of the sciatic nerves of the conscious rats. The possible mechanism of the nociceptive afferent impulses in producing traumatic shock is discussed. The author believes that the nociceptive afferent impulses (esp. painful impulses) which suddenly interupt the cortical and subcortical activity, should be the major cause of primary shock here described. In view of the present experiment, the importance of early removal of the local stimulating agents and blocking the local nerves for 15-20 minutes in the prevention and management of surgical shock, is indicated.
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