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feng shi xing xin zang bing xin ji - shou ti mrna zhuan lu de gai bian
Author(s): 
Pages: 39-40+46
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  风湿性心脏病心肌受体.肾上腺素能.β基因;
Abstract: 目的:研究风湿性心脏病(风心病)心肌β-肾上腺素受体(β-AR)功能改变的分子机制。方法:采用斑点杂交法测定风心病患者与正常人心肌β1-及β2-ARmRNA转录的变化。结果:心肌β1-ARmRNA转录水平,风心病心功能Ⅳ级组较心功能Ⅱ~Ⅲ级组和正常对照组均显著下降(P<0.05,0.01),而β2-ARmRNA转录水平各组间无明显差异(P>0.05)。结论:风心病慢性心力衰竭时β1-ARmRNA转录减少是引起心肌总β-AR密度下降的主要原因。
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