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zai zheng chang he guan zhuang dong mai xia zhai quan zhong kuo zhang wei dui guan mai xue liu dong li xue de ying xiang
Pages: 285-292
Year: Issue:  3
Journal: Acta Physiologica Sinica

Keyword:  distention of stomachcoronary blood flowcoronary stenosisperipheral coronary pressurecoronary vascular resistance;
Abstract: It has long been known that food intake or distention of the stomach affectscardiovascular function, but the conclusion remains controversial. Previous ex-periments were made on animals with normal coronary circulation. In this paper,the effect of distention of the stomach was studied in dogs with either normal orstenosed coronary artery. In 22 open-chest mongrel dogs, critical and severe stenosis were produced onleft circumflex coronary artery (CX) with a micrometer constrictor. A large balloonwas placed into the stomach and inflated with 600 ml of air. The postdistentioneffect was observed for 30 min. The response to distention of the stomach wasbiphasic. At the early stage of stomach distention in dogs with normal coronaryartery, left circumflex coronary blood flow(Fcx) was increased, mean arterial pressure(Pa) rose, resistance of CX was reduced, and CX vasodilation occurred. All thesechanges recovered within a quarter to half an hour. In critical coronary stenosis,CX vasodilation occurred first, then followed by a decrease of Fcx, the resistanceof distal vascular bed (R_2) increased as a result of vasoconstriction. In severecoronary stenosis, at first Fcx was unchanged, but then decreased remarkably,R,R_2 and the resistance of proximal segment (R_1) rose, CX vasoconstriction oc-curred. It is suggested that postprandial angina pectoris be due to a reduction in coro-nary blood flow on the basis of coronary stenosis.
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