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jiu shi suan zuo zuo zuo you ri ben xue xi xi huo xi luan suo yin qi de jian kang jia tu zuo fan de ying zuo
Pages: 243-248
Year: Issue:  3
Journal: Acta Physiologica Sinica

Keyword:  酒石酸锑钾家免注射家兔病理生理日本健康血沉抑制直接作用;
Abstract: There is controversy in the literature about the action of potassium antimony tartrate (PAT) on the schistosome eggs in vivo while its action on schistosome worms, especially the female, is well known. Yokogawa, Hoeppli, and Faust were in favor of the view that PAT indeed exerts its direct action on schistosome eggs in vivo whereas Bang and Hairston were against it. All of them formed their view by basing on histological examination of the eggs embedding in the tissues or eggs in the stool of the infected animal. Our previous study has shown that a single inoculation of viable schistosome eggs into the portal circulation of the healthy rabbits could induce pathologico-physiological reactions, such as the increase of the erythrocyte sedimentation rate(ESR), etc., which were comparable to that of natural infection. The present work showed that the augmentated ESR produced by introducing viable schistosome eggs in the healthy rabbit could be markedly inhibited by a course of PAT. The net result of augmentated ESR inhibited by PAT was found of the same order as that by dead eggs (treated with 5% NH_4OH) or by saline injection (Fig. 1, 2). These results seem to suggest that viable schistosome eggs introduced in the healthy rabbit were apparently killed by PAT. However, the possibility of lowering of the reactive mechanism of the rabbit toward the viable schistosome eggs due to the influence of PAT still remains, since it has been reported that PAT at the toxic dosage of 10 mg/kg causes an inhibition of the central nervous system in the rabbit as shown by Hsu and Chang. In a parallel experiment, a single injection of sterilized normal saline into the portal circulation of the healthy rabbit elicited a temporary increase of ESR which was in the same magnitude as the effect of dead schistosome eggs. PAT did not show any inhibitory effect on the saline effect but on the contrary, the saline effect was slightly augmented. These results indicate that PAT at the dose level used in our experiment has no apparent effect on the reactive mechanism, and its action on the augmentated ESR in the healthy rabbit is evidently due to its inhibitory action on the schistosome eggs. The method described in the present report may be used for studying the effect of new drugs on schistosome eggs in vivo.
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