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Clinical significance of hemostatic molecular markers in acute leukemia
Author(s): 
Pages: 141-144
Year: Issue:  3
Journal: CHINESE JOURNAL OF HEMATOLOGY

Keyword:  白血病凝血致活酶纤维蛋白溶解;
Abstract: Objective To study the changes of hemostatic molecular markers in acute leukemia(AL) forelucidating their clinical significance. Methods A series of hemostatic molecular markers, including TF、 TFPI、TAT、PAP、u-PA and u-PAR were measured in 82 acute leukemia. Results The plasma levels of TF、TAT、u-PAand u-PAR were elevated significantly at diagnosis in all AL patients tested,while TFPI 、PAP did only in AML. Aftertreatment, TF and TAT remained high in AML, u-PA and u-PAR were still high in un-remission patients. PAP and u-PA remarkably elevated in patients with severe hemorrhage. Conclusions There existed hemostatic abnormalityas well as hyperfibrinolysis, which varied with leukemia types and was ameliorated with clinical improvement. Themeasurement of TF 、TAT and PAP may provide useful information for the diagnosis of DIC. u-PA and u-PAR may beconsidered as a useful indicator for prognosis. Patient with severe hemorrhage should be treated with antifibrinolysisdrugs. The prevention of hypercoagulability after treatment should be kept in mind.
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