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ci ji mi zou shen jing he suan hua shi er zhi chang dui gou yi ye fen mi de xiang hu ying xiang
Pages: 410-415
Year: Issue:  5
Journal: Acta Physiologica Sinica

Keyword:  vagal stimulation duodenal acidificationpancreatic protein outputpancreatic bicarbonate outputatropinelidocaine;
Abstract: Interaction of vagal stimulation and duodenal acidification on pancreatic se-cretion was studied in five dogs provided with chronic pancreatic and gastric fis-tulas.The results were as follows:(1)When the duodenal acidification,vagalimpulses potentiated pancreatic protein and bicarbonate output,which is morethan the additive sum obtained by the separate actions of the vagal stimulationand duodenal acidification.(2)When the vagus was stimulated immediatly follow-ing the cessation of pancreatic response to duodenal acidification,the latent periodbecame shorter, the protein and bicarbonate output were increased more than thatby vagal stimulation alone.(3)The pancreatic response to duodenal acidificationwas decreased significantly by administration of atropine or blockage of vagal im-pulses.(4)After duodenal infusion of lidocaine,the output of protein and bicar-bonate were also decreased significantly.From the above results it appears thatthe vagus nerve and the local nerves of the duodenal wall may play a part in themechanism of the pancreatic response to duodenal acidification.When the vagalimpulses and the endogenous secretin and pancreozymin act simultaneously onthe pancreas,the interaction of nerve and hormones appears potentiation.Oncethe vagal impulses are blocked,the action of the two gut hormones would be de-creased significantly.
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