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da shu ji sui zhong de shou ti zai jian ya fan she he shi xue xing xiu ke zhong de zuo yong
Pages: 132-138
Year: Issue:  2
Journal: Acta Physiologica Sinica

Keyword:  intrathecal injectionclonidinephentolamineblood pressureheart ratesympathetic nervous discharge;
Abstract: While there is general agreement that noradrenergic neurons in the brainstemsend descending fibers to the intermediolateral cell column of the spinal cord inthe rat, considerable controversy existed concerning the role played by these descend-ing pathways in the control of the cardiovascular function. In the present studyit was found that intrathecal injection of α-agonist clonidine (1μg) in the rat induceddecrease in blood pressure, heart rate and discharge of sympathetic postganglionicnerve (SND) originating from the celiac ganglion. Intrathecal administration ofα-receptor blocker phentolamine (10μg) significantly decreased the sensitivity ofthe baroreceptor reflex, as manifested by attenuation of reflex bradycadia andreflex inhibition of SND to the-rise of blood pressure produced by intravenous pheny-lephrine (2.5-15μg/kg). Moreover, in rats brought into hemorrhagic shockby bleeding via common carotid artery, intrathecal injection of phentolamine ac-celerated the recovery of blood pressure toward normal level. Our results indicatethat spinal α-receptors are important in mediating the cardiovascular depressoreffect, which may play an important role in the baroreflex and the pathophysiologyof hemorrhagic shock.
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