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feng shi xing xin zang bing xin ji xi bao - shen shang xian su shou ti fu he ti gong neng de bian hua
Author(s): 
Pages: 21-23
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  风湿性心脏病心肌细胞受体肾上腺素能β;
Abstract: 目的:探讨风湿性心脏病(风心病)心肌细胞β-肾上腺素受体(β-AR)复合体的功能变化。方法:采用31P核磁共振法,分别测定正常人与风心病患者心肌细胞β-AR复合体中β-AR、刺激型G蛋白(Gs)和腺苷酸环化酶(AC)等各组成成分经选择性激动剂刺激后生成cAMP的能力。结果:风心病患者心肌细胞粗制膜经β-AR激动剂异丙肾上腺素和Gs激动剂氟化钠刺激后生成cAMP量较正常对照显著下降(P<0.05,0.01),而经AC激动剂Forskolin刺激后生成cAMP量与正常对照无显著差异(P>0.05)。结论:风心病患者心肌细胞β-AR复合体的功能降低主要与β-AR及Gs蛋白的功能降低有关,而效应器AC的活性无明显变化。
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