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feng shi xing xin zang bing xin ji xi bao nei gai li zi zhuan yun dan bai ji yin zhuan lu de bian hua
Author(s): 
Pages: 41-43
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  风湿性心脏病心肌细胞钙离子转运蛋白基因转录;
Abstract: 目的:探讨风湿性心脏病(风心病)慢性心衰时心肌细胞内Ca2+转运功能改变的分子机制。方法:应用斑点杂交方法测定12例风心病患者心肌细胞内4种主要Ca2+转运蛋白:L-型钙通道(DHPR)α1亚基、钠钙交换体(NCE)、肌浆网钙泵(SERCA2)和肌浆网Ca2+释放通道-兰尼碱受体(RyR2)的基因转录变化。结果:风心病患者DHPRα1、SERCA2和RyR2mR-NA水平,以鸡磷酸-3-甘油醛脱氢酶(GAPDH)mRNA为内对照,分别较正常对照显著下降12.5%,31.6%和13.0%,以β-肌球蛋白重链(MHC)mRNA为内对照,则比正常对照分别显著下降8.9%、22.0%和9.0%;而NCEmRNA水平在两种内对照情况下分别显著升高56.0%和41.5%。结论:风心病慢性心衰时心肌细胞内Ca2+转运功能改变的机制很可能主要在转录水平。
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