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ci ji tu xia qiu nao jin zhong xian qu dui xin gong neng de ying xiang
Pages: 37-43
Year: Issue:  1
Journal: Acta Physiologica Sinica

Keyword:  下丘脑后部心功能损害升压反应心肌缺血心律失常心输出量室性早搏心电图每搏输出量心动过缓;
Abstract: After stimulation of the vicinity area near the midline of medial and pos-terior hypothalamus of anaesthetized rabbits with electrical impulses of frequency50 HZ,duration 0.5 msec and strength 0.25—0.5 mA,the blood pressure andthe left ventricular pressure increased,the pupil dilated.If the anaesthesia levelwas rather light,somatic movement had also been observed.Bradycardia,mis-sing of beats and other manifestations of arrhythmia(ventricular extrasystoles,ventricular tachycardia,etc.)were commonly observed whenever the pressor res-ponse was rather pronounced.Although the former two manifestations of ar-rhythmia disappeared,the extrasystoles could still be elicited by hypothalamicstimulation.However,this could be abolished together with the pressor responseby administration of α-receptor blocking agent(phentolamin)and abolished orattenuated by β-receptor blocking agent(propranolol),thus it was believed thatthe extrasystolic activity was due to β-activation and the effect of rising of arterialpressure caused by hypothalamic stimulation.This argument was strengthenedby the fact that the premature beat could also be elicited simply by increasing theload of the left ventricle bv retrograde injection of saline into the aorta.
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