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ji sui zhu wang mo xia qiang zhu she nao fei zuo lei si wu yin qi da shu xue ya jiang di he xin lv jian man
Author(s): 
Pages: 546-551
Year: Issue:  6
Journal: Acta Physiologica Sinica

Keyword:  intrathecal injectionenkephalin analogueδ-opiate siteblood pressureheart rate;
Abstract: The putative agonists of δ,K and μ opiate sites were injected intrathecallyto evaluate their cardiovascular effects in pentobarbital anesthetized rats.(1)Administration of δ agonists[D-Ala~2]-Met-enkephalinamide(40,80 nmol),[D-Ala~2]-Leu-enkephalin(50,100 nmol)and[D-Ala_2,D-Leu_5]-enkephalinamide(2.5,10,40 nmol)induced a dose-dependent decrease in mean arterial blood pressure(BP)and heart rate(HR).The rank order for the depressor and bradycardic ef-fects of enkephalin analogues was:[D-Ala~2,D-Leu~5]-enkephalinamide,[D-Ala~2]-Met-enkephalinamide and[D-Ala~2]-Leu-enkephalin,respectively.These effectscould be abolished by pretreatment with naloxone,an antagonist of opiate receptors.(2)No significant changes were found following the administration of ethylktocy-clazocine(100,500 nmol),the prototypical k agonist.Another k agonist dynor-phin was ineffective at a dose of 5 nmol,while a larger dose(10 nmol)lowered BPbut not HR.(3)No significant changes were induced by administration of proty-pical μ agonists morphine(150 nmol)and dihydroetorphine(0.1,0.5 nmol).The results suggest that δ opiate sites in spinal cord may play a more impor-tant role in the regulation of cardiovascular function than k andμsites
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