The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Bookmark and Share
ji sui zhu wang mo xia qiang zhu she nao fei zuo lei si wu yin qi da shu xue ya jiang di he xin lv jian man
Pages: 546-551
Year: Issue:  6
Journal: Acta Physiologica Sinica

Keyword:  intrathecal injectionenkephalin analogueδ-opiate siteblood pressureheart rate;
Abstract: The putative agonists of δ,K and μ opiate sites were injected intrathecallyto evaluate their cardiovascular effects in pentobarbital anesthetized rats.(1)Administration of δ agonists[D-Ala~2]-Met-enkephalinamide(40,80 nmol),[D-Ala~2]-Leu-enkephalin(50,100 nmol)and[D-Ala_2,D-Leu_5]-enkephalinamide(2.5,10,40 nmol)induced a dose-dependent decrease in mean arterial blood pressure(BP)and heart rate(HR).The rank order for the depressor and bradycardic ef-fects of enkephalin analogues was:[D-Ala~2,D-Leu~5]-enkephalinamide,[D-Ala~2]-Met-enkephalinamide and[D-Ala~2]-Leu-enkephalin,respectively.These effectscould be abolished by pretreatment with naloxone,an antagonist of opiate receptors.(2)No significant changes were found following the administration of ethylktocy-clazocine(100,500 nmol),the prototypical k agonist.Another k agonist dynor-phin was ineffective at a dose of 5 nmol,while a larger dose(10 nmol)lowered BPbut not HR.(3)No significant changes were induced by administration of proty-pical μ agonists morphine(150 nmol)and dihydroetorphine(0.1,0.5 nmol).The results suggest that δ opiate sites in spinal cord may play a more impor-tant role in the regulation of cardiovascular function than k andμsites
Related Articles
No related articles found