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THE EFFECTS OF CHOLERAL TOXIN ON THE REGENERATION OF THE RETINAL GANGLION CELLS IN GOLDEN HAMSTER
Author(s): 
Pages: 117-120
Year: Issue:  2
Journal: ACTA ANATOMICA SINICA

Keyword:  霍乱毒素坐骨神经视网膜节细胞轴突再生金黄地鼠;
Abstract: Objective The present study was aimed at investigating theeffects of cholera toxin(CTx) on promoting the regeneration of retinal ganglion cells(RGCs) in hamster retina. Methods After optic nerve (ON) tran section, an autologus sciatic nerve (attached graft, AG) was removed and sutured to the proximal stump of the ON. CTX was injected or (and) a small segment of sciatic nerve (SN) inserted intravitrously. Animals were separated into 5 group s:regenerating control group(AG groups and solution groups); AG+CTX groups; AG + SN groups; AG+CTX+SN groups; Effect and Dosage groups; Animals in the former 4 groups were allowed to survive for 2-6 weeks respectively. The regenerated RGC s were labeled retrogradely by granular blue, and the changes in number of rege nerating RGCs in each retina were observed under fluorescent microscope. Results The mean numbers of regenerating RGCs in AG+CTX groups were inc reased and significantly higher than those in AG groups and solution groups at e ach time point(P<0.05). Similar results were obtained in AG+SN groups; In AG+CTX+SN groups, the mean number of regenerating RGCs was markedly increa sed than those in the AG groups and AG+SN groups at each time point (P<0.01 ). Conclusion Our results indicated that injection of CTX or/and insertion of SN intravitrously could enhance the regeneration of the axotomized RGCs significantly.
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