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EFFECTS OF BOTH GDNF AND HSV-GDNF ON Bcl-2 EXPRESSION IN SPINAL CORD MOTOR NEURONS AFTER SCIATIC NERVE INJURY IN RATS
Author(s): 
Pages: 132-135
Year: Issue:  2
Journal: ACTA ANATOMICA SINICA

Keyword:  胶质细胞源性神经营养因子(GDNF)单纯疱疹病毒(HSV)载体Bcl-2脊髓运动神经元;
Abstract: Objective To observe the effects of GDNF and HSV-GDNF on B cl-2expression in spinal cord motor neurons after sciatic nerve injury in rats . Methods Lumbar of spinal cord was immunohistochemically stained b y using the antiserum of Bcl-2.The number and mean optical densities of Bcl-2 i mmunoreactive(Bcl-2-IR)positive neurons were counted and observed. Results The number and mean optical densities of Bcl-2-IR positi ve neurons were significantly increased in GDNF and HSV-GDNF 4 days and 7 days after sciatic nerve injury.But differences of the number and the mean optical de nsities of Bcl-2-IR positive neurons were not obvious in three groups 14 days after sciatic nerve injury. Conclusion Local application of GDNF and HSV-GDNF to transected s ciatic nerve can prevent the massive neuron apoptosis or programmed cell death i nduced by nerve injury.
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