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feng shi xing xin zang bing ban mo ti huan shu hou nei du su ji xi bao yin zi xue jiang nong du de bian hua
Author(s): 
Pages: 49-51+54
Year: Issue:  S1
Journal: Academic Journal of Second Military Medical University

Keyword:  风湿性心脏病瓣膜替换术内毒素肿瘤坏死因子白细胞介素-1白细胞介素-6;
Abstract: 目的:观察风湿性心脏病(风心病)瓣膜替换术中体外循环(CPB)对内毒素及炎性细胞因子肿瘤坏死因子(TNF)、白介素(IL)-1和IL-6血浆浓度的影响。方法:分别应用鲎变形细胞溶解物实验、放射免疫分析法及MTT法测定风心病瓣膜替换手术围术期各时间点血浆内毒素及炎性细胞因子TNF、IL-1和IL-6的浓度。结果:风心病瓣膜替换术CPB后早期血浆内毒素及TNF、IL-1和IL-6浓度明显升高,但可在短期内降至术前水平。结论:血浆内毒素及TNF、IL-1和IL-6浓度的升高在风心病瓣膜替换术后早期CPB对机体所产生的不良影响中起到重要的作用,但可能并不对预后产生直接的影响。
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