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ben hai la ming dui han fang ji ji qi ta yi xie zhen tong yao de jia qiang zuo yong
Pages: 133-141
Year: Issue:  2
Journal: Acta Physiologica Sinica

Keyword:  苯海拉明汉防己甲素小白鼠镇痛作用乙素加强作用镇痛药流浸膏千克毒性作用;
Abstract: Experimental studies with a modified Beer.Grewal's method for testing analgesia has been undertaken with the following results: (1)The alkaloids tetrandrine and demethyl-tetrandrine,the decoction and the extract of Han-fang-chi(汉防己),the root of Stephania tetrandra S.Moore,all possess definite but mild analgesic action in mice.The minimal effective doses of tetrandrine and dernethyl-tetrandrine are 30 and 60 mg/kg,while the LD_(50) by subcutaneous administration are 804 and 397 mg/kg re- spectively.The analgesic index of tetrandrine is,therefore,higher than demethyltetrandrine. (2)Within certain dosage range,the analgesic action of these two alkaloids and the ex- tract is diminished as the dosage is increased.This may be related to the fact that the central stimulating effects of these drugs become predominant in the larger doses.At such high do- sages,tetrandrine intensifies the strychnine toxicity and shortens the pentobarbital-induced sleep- ing time in mice. (3)The analgesic action of tetrandrine and demethyl-tetrandrine,as well as of morphine, demerol and antipyrine is markedly enhanced by diphenhydramine hydrochloride.This com- pound does not.however,significantly alter the LD_(50) of these analgesics.The mechanisms of this potentiation is discussed.
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