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jia zuo hai deng shi ji ke shi xiao wei fen mi de ying zuo
Pages: 224-230
Year: Issue:  3
Journal: Acta Physiologica Sinica

Keyword:  胃分泌小胃分泌量胃液量胃泌素迷走奴佛卡因胃液分泌硫酸阿托品刺激;
Abstract: The experiments were doneon dogs with esophageal fistula and Heidenhain or Bickel pouch to observe the effect of sham feeding on the gastric secretion. The experimental dogs were fed at 3 o'clock in the afternoon, and then no food was given until 8 o'clock next morning. Gastric secretion from the pouch was collected every 15 minutes till the quantity was less than 1 cc and HC1 was negligible. Then sham feeding was given for 5 minutes and then discontinued for 5 minutes; this procedure was repeated 3 times, making 30 minutes in total. In the meanwhile the gastric secretion from the pouch was again collected every 15 minutes for 2—3 hours. The acid was estimated by titration with N/100 NaOH and calculated as mg HC1 in every 15 minutes. The results were as follows: It was observed on 4 dogs that the secretion of acid from all but one of the Bickel pouches occurred after sham feeding either immediately or after a latent period of 15-30 minutes (Table 1). Another 3 dogs with Bickel pouch and fistula of the main stomach responded to sham feeding with marked increase in the acid secretion. The same result was also observed on 2 dogs with Heidenhain pouch and fistula of the main stomach. By making a mucosa septum between the pyloric antrum and the main stomach, so that the secretion of the main stomach would not pass through pylorus but discharged to the intestine through the gastro-intestinal anastomosis at the greater curvature, a marked increase in secretion from Bickel pouch was also observed after sham feeding in 2 dogs (No. 28, 29). In either of the above conditions (Bickel pouch and fistula of the main stomach, or Heidenhain pouch and fistula of main stomach, or pyloric antrum separated from the main stomach by mucosa septum) an intravenous injection of 1-2 mg of atropine sulphate 5 minutes before sham feeding markedly reduced the secretion in the Bickel or Heidenhain pouches (Figs. 1, 2, 3). Cutting the vagus nerve supply to the separated pyloric antrum (dog No. 29) also produced the same result (Fig. 5). When dog No. 10 was put under light anesthesia by intravenous injection of 15 mg per kg of sodium pentobarbital and the peripheral end of the left vagus (cut 3 days before the experiment) was stimulated with induction shock, the secretion rate in the Heidenhain pouch was increased which could be again reduced by an intravenous injection of 2 mg atropine sulphate (Fig. 4). These results support the view that the vagus is related to the gastric phase of the secretion and that the change of the reaction in the pyloric antrum from alkaline to acid will reduce the secretion of the body of the stomach,
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