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Oral vaccination of sea perch,Lateolabrax japonicus,against Vibrio anguillarum using microencapsulated vaccine
Author(s): 
Pages: 76-79
Year: Issue:  2
Journal: JOURNAL OF FISHERY SCIENCES OF CHINA

Keyword:  鳗弧菌口服微胶囊疫苗疫苗制备鲈鱼免疫;
Abstract: 以分离自患病鲈鱼(Lateolabrax japonicus)的致病菌W-1为材料,利用喷雾微胶囊技术制备口服微胶囊疫苗。结果表明,喷雾干燥条件对疫苗微胶囊颗粒影响较大;其适宜条件为:进料温度40℃,进料速度40 ml/min,热风温度200℃;其制备的微胶囊疫苗平均粒径为45.5 μm,平均含菌量为2.79×109 mg-1干粉。将此微胶囊疫苗及全细胞疫苗直接拌入饵料口服免疫接种鲈鱼幼鱼,1周后以W-1活菌攻毒(2.5×106 CFU/尾)。结果表明,微胶囊疫苗组的1周累积死亡率(41.7%)低于全细胞疫苗组(45.0%),均低于对照组(95.0%)。2个免疫组都有一定的免疫保护力,微胶囊疫苗组和全细胞疫苗组的免疫保护力分别为56.1%和52.6%。
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