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Development on PI3K/mTOR signaling pathway and the dual inhibitor NVP-BEZ235
Author(s): 
Pages: 172-176
Year: Issue:  3
Journal: World Clinical Drugs

Keyword:  PI3K/Akt/mTOR信号通路双重抑制剂抗肿瘤药物;
Abstract: 磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路与肿瘤的发生发展密切相关.PI3K/mTOR双重抑制剂已成为抗肿瘤药物研发的热点之一.近年,NVP-BEZ235因其能有效并特异性地双重抑制PI3K/mTOR信号通路的异常活化而受到关注.本文综述PI3K/Akt/mTOR信号通路及NVP-BEZ235的开发.
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