xin zhi zhuan lu yin zi de yan jiu jin zhan
Author(s): XU Ming, SHEN Baozuo
Pages: 238-241
Year: 2009 Issue: 3
Journal: Chinese Journal of Otorhinolaryngology-Skull Base Surgery
Keyword: KLF4; 转录调节; 机制;
Abstract: 胃肠富集Krupple样因子4(GKLF,亦称KLF4)是Krupple样转录因子(KLF)家族的成员之一,该家族成员包括KLF1-16,不同的成员分布不同,其功能也互有不同,例如KLF1主要表达在红细胞,KLF2主要在肺内表达,而KLF4因首先在小鼠去血清处理的NIH3T3细胞cDNA文库中获得该基因,而其表达主要在胃肠道上皮,因此得名胃肠富集Krupple样因子,也叫表皮锌指因子(EZF)。它是一种真核锌指蛋白转录因子,通过激活或抑制其目的基因的转录来调控基因的时相性及其在细胞和组织中的特异性表达。近年来研究发现,KLF4基因及其蛋白有着更为广泛的作用,它们的低表达或高表达以及与其他相关因
Pages: 238-241
Year: 2009 Issue: 3
Journal: Chinese Journal of Otorhinolaryngology-Skull Base Surgery
Keyword: KLF4; 转录调节; 机制;
Abstract: 胃肠富集Krupple样因子4(GKLF,亦称KLF4)是Krupple样转录因子(KLF)家族的成员之一,该家族成员包括KLF1-16,不同的成员分布不同,其功能也互有不同,例如KLF1主要表达在红细胞,KLF2主要在肺内表达,而KLF4因首先在小鼠去血清处理的NIH3T3细胞cDNA文库中获得该基因,而其表达主要在胃肠道上皮,因此得名胃肠富集Krupple样因子,也叫表皮锌指因子(EZF)。它是一种真核锌指蛋白转录因子,通过激活或抑制其目的基因的转录来调控基因的时相性及其在细胞和组织中的特异性表达。近年来研究发现,KLF4基因及其蛋白有着更为广泛的作用,它们的低表达或高表达以及与其他相关因
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