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Efficacy of concurrent or induction pemetrexed chemotherapy combined with 3D-radiotherapy for NSCLC
Author(s): YOU Sheng-yong, ZhOU Jiang-yun, PENG Kang-ming
Pages: 255-
257
Year: 2013
Issue:
3
Journal: Chinese Journal of Clinical Oncology and Rehabilitation
Keyword: 非小细胞肺癌; 三维适形放疗; 诱导; 培美曲塞; 顺铂;
Abstract: 目的探讨三维适形放疗联合培美曲塞和顺铂治疗非小细胞肺癌(NSCLC)同步和诱导方案的疗效。方法将56例NSCLC患者随机分为同步组(28例)和诱导组(28例)。均采用加速器6MV的X线三维适形放疗,总剂量60~70 Gy。诱导组放疗前行3个周期的培美曲塞(500mg/m2,第1天)和顺铂(20mg/m2,第1~3天)放疗诱导,放疗同时再给予化疗2个周期;同步组放疗当日给予培美曲塞(500mg/m2,第1天)和顺铂(75mg/m2,第1~3天)化疗3个周期。结果诱导组近期疗效显著高于同步组,造血系统毒性和胃肠道不良反应较轻。结论诱导方案能有效提高近期疗效,且不良反应较轻,是治疗NSCLC的较好方案。
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