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Inhibition of proliferation and induction of apoptosis by simvastatin in K562 le ukemic cell line
Pages: 72-75
Year: Issue:  2

Keyword:  斯伐他汀白血病髓样慢性细胞凋亡;
Abstract: Objective To investigate the anti-apoptotic mechanism and explore approach to inhibiting proliferation and inducing apoptosis of chronic myclogenous leukemia (CML) cel ls. Methods K562 cell line was used to evaluate the effects of simv astatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) red uctase, and the combination of simvastatin with chemotherapeutic agents on the proliferation and apoptosis of CML cells. Results Simvastatin c ould significantly inhibit proliferation and induce apoptosis of K562 cells,and could increase the sensitivity of K562 cells to chemotherapeutic agents. Additi on of mevalonate, the immediate product of HMG-CoA, could completely reverse th is effect. Conclusion  Simvastatin inhibited proliferation and induced apoptosis of K562 cells through inhibiting the metabolic pathway of mevalonate. It is promising that HMG-CoA re ductase inhibitors may be an effective chemotherapeutic approach to the treatmen t of CML.
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