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Immunorelated pancytopenia
Author(s): 
Pages: 79-82
Year: Issue:  2
Journal: CHINESE JOURNAL OF HEMATOLOGY

Keyword:  全血细胞减少症异常免疫;
Abstract: Objective A report of a group of patients with pancytopenia which might be related to abno rmal immunity. Methods The clinical and laboratory features of 29 p atients with positive bone marrow mononuclear cell(BMMNC) Coombs tests were anal yzed. Results Most of these cases were pancytopenia with normal o r decreased bone marrow cellularities and increased normoblasts. They were all f ound to have negative results of conventional hemolysis tests and hematopoietic nutrient determination and had no evidence of malignant clonal hematopoiesis. Ho wever, all of them showed positive BMMNC-Coombs test and good response to corti costeroids. Conclusion Immunorelated pancytopenia might be cause d by abnormal immunity (especially autoantibody) mediated destruction or abnorma l function of blood cells. It is beneficial to differentiate immunorelated pancy topenia from aplastic anemia or myelodysplast ic syndromes.
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