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Expressions of P-gp, mdr1, MRP and Topo Ⅱ in acute leukemia patients and their correlation with prognosis
Author(s): 
Pages: 90-93
Year: Issue:  2
Journal: CHINESE JOURNAL OF HEMATOLOGY

Keyword:  白血病抗药性多药基因表达;
Abstract: Objective To investigate whether P-gp, mdr1, MRP and Topo Ⅱ are the prognostic factors o f clinical resistance in acute leukemia (AL) patients. Methods Th e expression of P-gp was analyzed by flow cytometry using monoclonal antibody U IC2, the expressions of mdr1, MRP and Topo Ⅱ by RT-PCR in 45 AL samples. Results The expressions of P-gp, mdr1 and MRP were significantly high er in resistant group than that in sensitive group(P<0.01). The expr ession of Topo Ⅱ was lower in resistant group, but the difference was not stati stically significant. Logistic regression of univariate analysis showed that t he overexpression of P-gp, mdr1 and MRP, the lower expression of Topo Ⅱ and a ge over 55 were the prognostic factors of clinical resistance in AL. Sex, initi al white blood cell count (WBC), bone marrow (BM) blast percentage and FAB subty pes were not significant for the clinical resistance. Multivariate analysis adju sted by above factors showed that the overexpression of P-gp, mdr1 and MRP, the low expression of Topo Ⅱ and age over 55 were still highly significant for cli n ical resistance. It was also found that there were significant correlations betw een P-gp, mdr1, MRP and complete remission in 36 newly diagnosed AL. Significan t correlations were observed between P-gp and mdr1, mdr1 and MRP,and P-gp and MRP expression in all AL cases and in clinical resistance group(P<0 .001). Conclusions The overexpression of P-gp, mdr1 and MRP, and the lower exp re ssion of Topo Ⅱ are the unfavorable prognostic factors of clinical resistance i n AL. There is correlation between mdr1 and MRP expressions.
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