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Chromosome t(8;21) and t(15;17) in a patient with acute myeloid leukemia
Pages: 94-95
Year: Issue:  2

Keyword:  白血病髓细胞性急性染色体异位核型分析;
Abstract: Objective To report an acute myeloid leukemia (AML) patient with both chromosome t(8;21) a nd t(15;17). Methods Chromosome specimen was prepared by short-t erm culture of bone marrow cells, karyotype analyses by R-banding technique, an d fusion genes by reverse transcriptase-polymerase chain reaction (RT-PCR). Result Karyotype analyses showed the appearance of 45, X, -X,t(8;21 ),t(15;17), and RT-PCR assay revealed AML1/ETO and PML-RARα fusion gene tran scripts. Conclusion AML with both t(8;21) and t(15;17) might be r ecognized as a a novel subtype of acute leukemias.
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