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Issue:
Effect of TCDCA on the splenocyte immunity stimulanted by mitogen in mice
Author(s):
LI Pei-Feng
,
SHI You-Fei
,
GUAN Hong
Pages:
12
-
14
Year:
2007
Issue:
11
Journal:
HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE
Keyword:
牛磺鹅去氧胆酸
;
小鼠脾淋巴细胞
;
免疫调节
;
Abstract:
为了探讨牛磺鹅去氧胆酸(TCDCA)对有丝分裂原刺激的小鼠脾淋巴细胞免疫功能的影响,设计了TCDCA的0.01,0.05,0.1,1,10 μg/mL 5个剂量浓度梯度,开展了TCDCA对有丝分裂原刺激的小鼠脾淋巴细胞增殖反应、分泌IL-2和IgG的影响研究.结果表明:TCDCA对ConA刺激的脾淋巴细胞增殖反应表现出调节作用,对LPS刺激的脾淋巴细胞无明显作用;TCDCA对ConA和LPS刺激的脾淋巴细胞的分泌IL-2表现出向上抛物线形式的明显的调节作用;TCDCA对LPS刺激的脾淋巴细胞分泌IgG具有向下抛物线形式的明显的调节作用.说明TCDCA对有丝分裂原刺激的小鼠脾淋巴细胞免疫功能具有明显的调节作用.
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