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Progress of the interaction between Exosomes and M. tuberculosis
Author(s): CHEN Cai, WANG Jianjun, TANG Lijun Molecular Biology Research Center, School of Biological Science and Technology, Central South University, Changsha 410078, China
Pages: 177-
179
Year: 2013
Issue:
2
Journal: Immunological Journal
Keyword: 外泌体; 结核分枝杆菌; 巨噬细胞; 疫苗;
Abstract: 结核病是目前世界各国重点防控传染性疾病之一。外泌体(exosomes)是多种细胞分泌的一种含有特异性与非特异性蛋白成分的囊泡结构,是机体免疫细胞之间重要的信息传递介质,其在机体免疫反应中发挥着重要作用。外泌体能呈递表面抗原,激活多种细胞免疫因子,介导巨噬细胞杀伤结核杆菌的细胞免疫反应。外泌体与结核分枝杆菌相互作用研究已经成为当前重大研究热点,有望开发成预防结核病的新型疫苗。
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