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su zhou di qu 2010-2011 nian gao ling yun fu yun zhong qi chan qian shai cha ji ren shen jie ju
Author(s): 
Pages: 139-140
Year: Issue:  2
Journal: Journal of Nantong University(Medical Sciences)

Keyword:  产前筛查孕中期高龄妊娠结局;
Abstract: 目的:评价苏州地区高龄孕妇于孕中期行产前血清学二联指标筛查的可行性.方法:分析苏州市立医院2010-2011年间自愿进行孕中期血清学二联指标筛查的高龄孕妇637例,对其妊娠结局进行随访,并与这段期间低龄组(至预产期时的年龄≤35岁)进行比较.结果:筛查的高龄孕妇中,随访成功473例,其中低风险383例,唐氏综合征(Down's syndrome,DS)高风险82例,爱德华氏综合征(Edward's syndrome,ES)高风险6例,神经管缺陷(neural tube de-fects,NTD)高风险2例.DS高风险中确诊DS和特纳综合征各1例.NTD高风险中1例死胎.筛查低风险孕妇中1例心脏超声异常行羊水产前诊断确诊为DS.较之低风险孕妇具有更高的筛查效率.结论:苏州地区高龄孕妇行孕中期血清学二联指标筛查,筛查效率高于低龄孕妇,可以有效地提高高龄孕妇妊娠胎儿患DS的检出率,降低羊膜腔穿刺率.因此,在知情同意的基础上,对苏州地区高龄孕妇采用个体化的胎儿产前筛查和诊断策略是可行的.
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