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Express of proteasome subunit LMP-2, Survivin and Caspase-3 in missed abortion patients
Author(s): 
Pages: 94-97,封3
Year: Issue:  2
Journal: Journal of Nantong University(Medical Sciences)

Keyword:  稽留流产凋亡蛋白酶体亚基低分子质量多肽-2半胱氨酸蛋白酶-3生存素;
Abstract: 目的:检测稽留流产绒毛及蜕膜组织中蛋白酶体亚基低分子质量多肽-2(proteasome subunit low molecu-lar weight polypeptide 2,LMP-2)、半胱氨酸蛋白酶-3(cysteine-containing aspartate specific protease 3,Caspase-3)、生存素(Survivin)的表达,旨在探讨稽留流产的发病机制.方法:采用免疫组织化学染色方法检测30例稽留流产(实验组)患者绒毛及蜕膜组织中LMP-2、Caspase-3、Survivin的表达,并以30例正常早孕人工流产绒毛及蜕膜组织为对照组.结果:稽留流产组绒毛及蜕膜中LMP-2、Survivin的表达均低于正常早孕组,Caspase-3的表达则高于正常早孕组,差异均有统计学意义(P<0.05).实验组的绒毛及蜕膜Caspase-3与LMP-2及Survivin的表达均呈负相关,LMP-2与Survivin的表达呈正相关(P<0.05).结论:LMP-2、Survivin及Caspase-3的异常表达在稽留流产的发生中起重要作用.
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