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The effect of chloroquine on the autophagy of macrophage induced by Salmonella enterica serovar Typhimurium
Pages: 79-82,封2
Year: Issue:  2
Journal: Journal of Nantong University(Medical Sciences)

Keyword:  鼠伤寒沙门菌巨噬细胞氯喹自噬;
Abstract: 目的:研究氯喹对鼠伤寒沙门菌诱导巨噬细胞(macrophage,Mφ)自噬的影响.方法:确定氯喹干预感染模型的工作浓度,应用该浓度下的氯喹分别干预携带毒力质粒的野生株x3306和消除了毒力质粒的突变株x3337与小鼠腹腔MΦJ774A.1的感染模型,探讨氯喹影响细菌与MΦJ774A.1自噬的机制.结果:20 μmol/L氯喹单独作用6h对细胞和细菌无显著影响;但干预感染模型后,却能阻断自噬.结论:鼠伤寒沙门菌毒力质粒参与了自噬早期过程.
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