A study of genetic polymorphism of the STR locus D2S441 in Chinese Han population in Chengdu
Author(s): HUANG Daixin, ZHANG Lin, WU Meizuo, CHEN Guodi, CHEN Yubo
Pages: 15-16,18
Year: 2001 Issue: 1
Journal: JOURNAL OF FORENSIC MEDICINE
Keyword: 短串联重复序列; 聚合酶链反应; D2S441位点; 多态性;
Abstract: Using PCR and PAG, followed by silver staining, the tetrameric STR D2S441 locus was studied in 260 unrelated Chinese individuals living in Chengdu. 9 alleles and 26 genotypes were observed. The range of fragment size was 131bp to 155bp. The genotype distribution of D2S441 locus in Han population was in accordance with Hardy-Weinberg equilibrium. Family survey confirmed Mendelian inheritance of alleles. The discriminating power (Dp), observed heterozygosity (H), polymorphism information content (PIC) and power of exclusion (PE) were 0.9084, 0.7885, 0.7390 and 0.5778 respectively. The results demonstrated that this locus was highly polymorphic and could be used for forensic identification and paternity testing.
Pages: 15-16,18
Year: 2001 Issue: 1
Journal: JOURNAL OF FORENSIC MEDICINE
Keyword: 短串联重复序列; 聚合酶链反应; D2S441位点; 多态性;
Abstract: Using PCR and PAG, followed by silver staining, the tetrameric STR D2S441 locus was studied in 260 unrelated Chinese individuals living in Chengdu. 9 alleles and 26 genotypes were observed. The range of fragment size was 131bp to 155bp. The genotype distribution of D2S441 locus in Han population was in accordance with Hardy-Weinberg equilibrium. Family survey confirmed Mendelian inheritance of alleles. The discriminating power (Dp), observed heterozygosity (H), polymorphism information content (PIC) and power of exclusion (PE) were 0.9084, 0.7885, 0.7390 and 0.5778 respectively. The results demonstrated that this locus was highly polymorphic and could be used for forensic identification and paternity testing.
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