The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
Effect of Water-soluble Small Molecule Extract in Anemarrhenae Rhizoma on Glucose Metabolism in Insulin-resistant HepG2 Cells
Author(s): 
Pages: 26-28
Year: Issue:  1
Journal: Food and Drug

Keyword:  HepG2细胞 胰岛素抵抗 知母 糖代谢;
Abstract: 目的研究知母水溶性小分子提取物的制备及其对胰岛素抵抗HepG2(IR-HepG2)细胞糖代谢的作用。方法采用水提取,膜分离方式制备知母提取物;采用高浓度胰岛素持续作用于HepG2细胞24 h建立胰岛素抵抗模型,加入知母水溶性小分子提取物保温24 h后,测定对照组和加药组细胞内葡萄糖消耗量、肝糖原含量及己糖激酶(hexokinase,HK)、丙酮酸激酶(pyruvate kinase,PK)的活性。结果知母水溶性小分子提取物明显增加细胞的葡萄糖消耗、提高IR-HepG2细胞HK、PK活性,增加肝糖原含量。结论知母水溶性小分子提取物可明显改善胰岛素抵抗状态下HepG2细胞对葡萄糖的利用,提高肝HK、PK活性,促进葡萄糖进入肝细胞,增加肝糖原合成,促进糖代谢。
Related Articles
No related articles found