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Preventive effect of alprostadil on contrast-induced nephropathy in patients undergoing coronary intervention
Author(s): 
Pages: 34-36
Year: Issue:  4
Journal: Chinese Journal of Postgraduates of Medicine

Keyword:  AlprostadilContrast-induced nephropathyPrevention;
Abstract: 目的 观察前列地尔对冠状动脉介入诊疗术患者造影剂肾病(CIN)的预防作用.方法 将215例接受冠状动脉介入诊疗术患者按随机数字表法分为治疗组(1 12例)和对照组(103例),对照组给予常规治疗,治疗组在常规治疗的基础上从术前1d开始给予前列地尔10 μg+0.9%氯化钠10ml静脉推注,每天2次,连用7~ 10d.观察两组的合并症及CIN发生情况等.结果 治疗组CIN发生率明显低于对照组[7.1%(8/112)比18.4%(19/103),P<0.05].肾功能不全患者CIN发生率明显高于肾功能正常患者[51.6%(16/31)比6.0%(11/184),P<0.01].糖尿病患者CIN发生率明显高于非糖尿病患者[22.1%(15/68)比8.2%(12/147),P< 0.01].结论 在行冠状动脉介入诊疗术前给予患者前列地尔能明显减少CIN的发生,要注意肾功能不全和糖尿病患者更易发生CIN.
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