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Preparation and stability of proanthocyanidin liposomes by thin film-extrusion method
Author(s): DING Bao-miao
Pages: 252-
255
Year: 2013
Issue:
2
Journal: Food Science and Technology
Keyword: 原花青素; 脂质体; 薄膜-挤压法; 微孔滤膜;
Abstract: 为了增加原花青素的稳定性,采用薄膜―挤压法制备原花青素脂质体,优化了制备处方和工艺条件。实验结果显示,胆固醇与卵磷脂质量比为0.1,芯壁比为0.1,吐温80与卵磷脂之比为0.5,脂质体有最大包封率64.76%。然后选用孔径为0.2μm的微孔滤膜,将脂质体挤出10次以降低其粒径。体外释放结果表明,原花青素脂质体在模拟胃肠液中10h表现出很好的稳定性。因而,脂质体对原花青素有较好的缓释和保护效果。
Citations
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