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The protective effect of Tetramethylpyrazine on kidney while performing ESWL(Extracorporeal Shock Wave Lithotripsy)
Author(s): 
Pages: 139-140,157
Year: Issue:  3
Journal: Surgical Research and New Technique

Keyword:  ESWL 肾损害 川芎嗪;
Abstract: 目的探索使用活血化瘀药川芎嗪保护家兔ESWL后肾功能的效果。方法以家兔(20只,2~3kg)为研究对象,随机分为实验组10只(20%川芎嗪4ml/kg,肌注)和对照组10只,以硫喷妥钠50mg/kg麻醉,切除右肾,左肾门处放置一银夹后制成结石动物模型,饲养两周,行ESWL治疗,测定ESWL前、后第1、3、5天家兔血中Cr、Bun、NO;并在第3、7天分别处死其中各3只,取肾组织观察形态和结构。结果用药组ESWL后血中Cr、Bun、NO升高不明显而非用药组中Cr、Bun、NO明显升高(P<0.05);光镜和电镜的组织结构显示,用药组的组织损伤轻于未用药组。结论川芎嗪能改善肾血流,增加肾内前列腺素的合成,减少血管紧张素,促进氧自由基的清除,对ESWL导致的急性肾功能损伤有保护作用。
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