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Purification of Botulinum Type a Neurotoxin and Its Toxoid’s Immunogenicity
Author(s): 
Pages: 49-51
Year: Issue:  4
Journal: Journal of Gansu Sciences

Keyword:  A型肉毒毒素纯化类毒素免疫原性;
Abstract: 采用阴离子交换柱层析法和凝胶过滤柱层析法纯化A型肉毒神经毒素复合物,通过SDS-PAGE法分析不同纯化条件下目标物的纯度和完整性,并以纯化物免疫BALB/c小鼠研究其免疫原性.结果显示,离子交换柱层析法纯化效果优于凝胶过滤柱层析法.
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