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Combined immunotherapy on peripheral blood Th1/Th2 ratio of patients with recurrent spontaneous abortion
Author(s): ZHAO Man-lin, LIN Xiao-min, ZHAN Bing, YANG Gui-yan, CHEN Ying-ting, LIANG Yan-xia
Pages: 496-
497,500
Year: 2012
Issue:
5
Journal: Journal of Guangdong Medical College
Keyword: 复发性自然流产; 免疫治疗; Th1/Th2平衡;
Abstract: 目的 观察联合淋巴细胞免疫、免疫球蛋白和阿司匹林的疗法对复发性自然流产(RSA)患者外周血Th1/Th2的影响.方法 31例RSA患者进行联合淋巴细胞免疫、免疫球蛋白、阿司匹林治疗,测定治疗前后外周血INF-γ、IL-10含量,计算Th1/Th2指标.结果 治疗后INF-γ较治疗前明显下降,IL-10较治疗前明显上升,Th1/Th2比值较治疗前明显下降,差异均有统计学意义(P<0.01).结论 RSA患者存在Th1/Th2平衡异常,联合免疫治疗可诱导Th1向Th2转移,恢复Th1/Th2平衡.
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