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Study on the correlation of killer immunoglobin-like receptor gene diversity with acute myeloid leukemia in the southern Chinese Han population
Pages: 426-429
Year: Issue:  5
Journal: Experimental and Laboratory Medicine

Keyword:  杀伤细胞免疫球蛋白样受体急性髓细胞白血病频率单倍型差异;
Abstract: 目的 研究和分析南方汉族急性髓细胞白血病(acute myeloid leukemia,AML)患者杀伤细胞免疫球蛋白样受体(KIR)的基因频率和单倍型.方法 采用序列特异性引物PCR (polymerase chain reaction with sequence-specific primers,PCR-SSP)技术对南方地区76例急性髓细胞白血病患者进行KIR基因的检测和分析,并与77例随机健康对照人群KIR基因频率进行比较.结果 共检出16个KIR基因;在AML患者中检出15种基因型,正常人群中检出18种基因型.结论 与正常人比较,AML患者各KIR基因频率无显著性差异.
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