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wei chi xing xue tou huan zhe xue qing ngal shui ping yu tou xi chong fen xing ji wei yan zheng zhuang tai de xiang guan xing
Author(s): 
Pages: 3079-3081
Year: Issue:  18
Journal: The Journal of Practical Medicine

Keyword:  NGAL透析充分性微炎症;
Abstract: 目的:本研究主要探讨在维持性血液透析患者,其血清中性粒细胞明胶酶相关载脂蛋白(NGAL)水平与透析充分性、炎症指标的关系,探讨血清NGAL水平对判断透析充分性的临床运用价值.方法:收集血液透析患者及健康对照人群的人口学资料、相关的临床和生化学资料及血清NGAL、CRP、转铁蛋白饱和度、TNF-α、IL-6、IL-1等情况.比较血清NGAL在不同组别的水平差异,做血清NAGL与spKt/V及炎症因子相关性分析.结果:(1)血液透析患者其血清NGAL水平为(445.45±50.34)ng/mL,较健康对照人群的(50.02±6.45) ng/mL明显升高,P<0.01.在血液透析患者组,其血清NGAL水平与spKt/V值呈正相关关系(R=0.652,P<0.05).单次透析均能显著降低血清NGAL水平.(2)入组150例透析患者中,95例据spKt/V值归为透析充分组.另55例归为透析不充分组.在透析充分组、透析不充分组,其血清NGAL水平分别为(589.14±56.34)ng/mL、(360.13±46.23) ng/mL,两组间血清NGAL水平差异有显著性(P<0.05).(3)在血液透析患者,血清NGAL水平与CRP、TNF-α、IL-6、TSAT(%)等指标均有正相关关系(P<0.05),但与IL-1及铁蛋白无明显线性关系(P>0.05).结论:在血液透析患者,血清NGAL与spKt/V有正相关性,与CRP、TSAT%、TNF-α、IL-6、有不同程度的正相关.
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