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Expression and clinical significance of growth hormone receptor in craniopharyngioma
Author(s): 
Pages: 3039-3041
Year: Issue:  18
Journal: The Journal of Practical Medicine

Keyword:  颅咽管瘤釉质上皮型鳞状乳头型GHR;
Abstract: 目的:探讨GHR在颅咽管瘤中的表达及意义.方法:前瞻性观察36例颅咽管瘤患者GHR的表达情况,其中21例釉质上皮型,设为釉质组;15例鳞状乳头型,设为鳞型组;5例对照组脑组织标本取自重型颅脑外伤行内减压术的正常脑组织.采用免疫组化、RT-PCR方法检测颅咽管瘤组织中GHR的表达.结果:与对照组相比,釉质组及鳞型组颅咽管瘤组织中,GHR表达明显增高,差异有统计学意义(P<0.05);与鳞型组相比,釉质组GHR表达明显增高,差异有统计学意义(P<0.05).结论:GHR可在颅咽管瘤组织中差异性表达,并可为颅咽管瘤术后替代治疗提供依据.
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