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Pharmacokinetics of recombinant human lymphotoxin-α derivate
Author(s): 
Pages: 662-665
Year: Issue:  11
Journal: World Clinical Drugs

Keyword:  重组人淋巴毒素α衍生物125I药动学;
Abstract: 目的评价重组人淋巴毒素α衍生物(rhLTαt-Da)在大鼠体内的药动学.方法大鼠静脉注射不同剂量125I标记重组人淋巴毒素α衍生物(125I-rhLTα-Da)后,采用同位素示踪法检测不同时间点的血液和尿粪标本中的总放射性量,血浆样本同时以三氯乙酸(TCA)沉淀法检测放射性量,分析药动学参数.结果大鼠静脉注射不同剂量(25、75和225 μg/kg)125I-rhLTα-Da,其血药浓度-时间曲线符合二室模型特征,血浆分布半衰期(tl/2α)分别为0.641、0.677和0.616 h (TCA沉淀法对应的t1/2α为0.626、0.632和0.594 h),消除半衰期(t1/2β)分别为11.356、13.373和16.033 h (TCA沉淀法对应的t1/2β为11.329、14.437和12.891 h),血药浓度-时间曲线下面积(AUC)和剂量呈正相关.结论rhLTα-Da在大鼠体内的吸收、分布和代谢符合二室模型特征,消除速度较慢,但不易蓄积.
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