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Effects of propofol on expression of inflammatory factor in acute autoblood pulmonary thromboembolism of rats
Author(s): 
Pages: 3696-3698
Year: Issue:  17
Journal: Chinese Journal of Gerontology

Keyword:  异丙酚肺栓塞炎性因子;
Abstract: 目的 观察异丙酚对急性肺栓塞(PTE)大鼠炎性因子的影响.方法 大鼠分为假手术组、模型组、异丙酚低、中、高剂量(4,8,16 mg/kg)组.制备急性自体血栓PTE模型.进行血气分析;检测肺系数、湿/干重(W/D);放射免疫法检测血液中内皮素(ET)-1、血栓素B2( TXB2)含量;RT-PCR检测肺组织白介素(IL)-1、IL-6、肿瘤坏死因子(TNF)-α mRNA的表达;Western印迹方法检测IL-1、IL-6、TNF-α蛋白的表达.结果 异丙酚能显著升高PO2、PCO2水平,降低肺系数、湿/干重、ET-1、TXB2含量,降低IL-1、IL-6、TNF-αmRNA和蛋白表达(P<0.05).结论 异丙酚能抑制炎性因子的表达,对PTE大鼠起保护作用.
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