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lao nian fa bing de lei feng shi guan jie yan huan zhe xue qing zhong liu huai si yin zi - shui ping
Author(s): 
Pages: 3621-3622
Year: Issue:  17
Journal: Chinese Journal of Gerontology

Keyword:  类风湿关节炎肿瘤坏死因子老年人;
Abstract: 目的 探讨肿瘤坏死因子-α(TNF-α)在老年发病的类风湿关节炎(EORA)发病机制中的作用.方法 采用酶联免疫吸附试验(ELISA)检测EORA患者(n=30)、青年发病的类风湿关节炎(YORA)患者(n=30)及健康对照者(n=30)血清TNF-α水平,并分析其与患者疾病活动度的关系.结果 EORA及YORA患者血清TNF-α水平明显高于健康对照组,EORA组患者血清TNF-α水平明显低于YORA组.EORA患者血清TNF-α水平与患者的疾病活动度呈明显正相关.结论 TNF-α在EORA患者发病及疾病进展中发挥重要作用,可作为监测EORA患者病情变化的指标.TNF-α在EORA及YORA发病中的作用机制可能存在差异.
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