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Lung Impairments of Embryonic Rat Induced by Prenatal Perfluorooctane Sulfonate (PFOS) Exposure
Author(s): 
Pages: 565-569
Year: Issue:  5
Journal: Asian Journal of Ecotoxicology

Keyword:  全氟辛烷磺酸盐胎鼠肺泡细胞血管内皮生长因子发育毒性;
Abstract: 为研究全氟辛烷磺酸盐(PFOS)暴露对胎鼠肺部损伤的诱导作用,孕期SD大鼠在5~ 20 mg·kg-1剂量范围内的PFOS中处理7d,取胎鼠全肺并分析其发育所受的影响.通过形态学比较,发现随着PFOS浓度的增加,胎鼠体长和体重均显著降低,高剂量暴露会导致胎鼠死亡.通过组织学检测,发现胎鼠肺的发育受到PFOS暴露的抑制.通过Western Blot检测肺泡Ⅰ/Ⅱ型细胞的发育,发现肺泡Ⅰ型细胞特异蛋白Podoplanin表达显著减少(p<0.05),肺泡Ⅱ型细胞特异蛋白SP-C表达减少但未出现显著差异,此外,与对照组相比高剂量暴露会引起血管内皮生长因子(VEGF)表达显著减少(p<0.01).实验结果说明,PFOS暴露会导致胎鼠肺部发育出现损伤,这种损伤可能是肺泡Ⅰ型细胞及肺部血管发育受抑制引起胎鼠肺部气体交换功能破坏.
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